Pharmaceutical Chemistry II

Structure, chemical classification, and SAR of antihypertensives, nitrates, and statins.

• Chemical classification and SAR of ACE inhibitors and ARBs
• Calcium channel blockers: 1,4-dihydropyridines chemistry
• Organic nitrates and vasodilator chemistry
• Beta-adrenergic receptor blockers SAR
• HMG-CoA reductase inhibitors (statins) chemical structure

Chemical structure and SAR of sedatives, hypnotics, antiepileptics, and analgesics.

• Barbiturates and benzodiazepines SAR and synthesis
• Hydantoin and iminostilbene antiepileptics
• Phenothiazine and butyrophenone antipsychotics
• Tricyclic and SSRI antidepressant chemistry
• Morphine alkaloids and synthetic opioid derivatives

Chemistry of alkylating agents, antimetabolites, and synthetic antimicrobials.

• Chemistry of alkylating agents (nitrogen mustards, nitrosoureas)
• Antimetabolites: folic acid, purine, and pyrimidine analogs
• Fluoroquinolones SAR and chemistry
• Antitubercular and antimalarial chemical agents

Steroid nomenclature, corticosteroids, sex hormones, and oral antidiabetic agents.

• Steroidal skeleton nomenclature and stereochemistry
• Glucocorticoids and mineralocorticoids SAR
• Estrogens, progestins, and androgens chemistry
• Sulfonylurea and biguanide antidiabetic chemistry

Chemical structures of water-soluble/fat-soluble vitamins, coenzymes, and radio-opaque contrast media.

• Chemistry of fat-soluble vitamins (A, D, E, K)
• Chemistry of water-soluble vitamins (B-complex, C)
• Coenzymes and biochemical significance
• Diagnostic dyes and iodinated contrast media